الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 137 |  |  |
| | | from | 137 | | |
Abstract
Soft tissue sarcomas are uncommon tumors accounting for about 1% of all malignant tumors mostly arise in adults. They can arise in any part of the body, but are most common in the extremities, specially the thigh and buttock. Soft tissue sarcomas represent a heterogeneous group of neoplasms which differ widely in their potential clinico-biological behavior, ranging from lesions with an indolent clinical course to lesions that behave in a highly aggressive manner. While certain tumors exhibit fairly consistent and predictable histopathological-specific behavior (confirming the importance of accurate histopathological classification), other lesions have a broad range of clinical behavior not immediately predictable from histopathological typing alone. Myxoid soft tissue tumors are a small, uncommon group of soft tissue tumors which are distinguished by their unique and consistent ability to produce abundant amount of myxoid ground substance along with the proliferating cells that constitute the tumor. This myxoid material is important for signal transduction, sequestration of growth factors, and receptor-ligand recognition during development and interactions between tumor cells. Together with their surrounding extracellular matrix, they play an important role in tumor progression and invasion Difficulty arises in the assessment of myxoid tumors for a variety of reasons including their rarity, morphological overlap, intratumor heterogeneity, mimicry of sarcomas by pseudosarcomas and the fact that there are few reliable immunohistochemical markers to aid in tumor subclassification.