الفهرس 
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Abstract
Escherichia coli (E.coli) affect poultry industry causing serious economic losses achieved by high morbidity and mortality, loss body weight and low egg production. The control of this microbe is an important for poultry farms and depends primarily on the prophylactic use of some antimicrobial agents such as florfenicol and tulathromycin. Florfenicol is a structural analogue of thiamphenicol is a new antibiotic possessing a wide spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria and so, it,s of great value in treatment of many respiratory and enteric infectious diseases. Tulathromycin is a semisynthetic macrolide antibiotic of the subclass triamilide intended for the treatment and prevention of bacterial respiratory disease in non-lactating cattle and pigs. The present study was conducted to evaluate some pharmacological studies on florfenicol and tulathromycin during colibacillosis in experimentally and naturally infected chickens by throwing light on possible; if any adverse effects of these drugs on blood picture, liver and kidney functions and immunity indices. In addition, their residues in some tissues (liver, kidney and muscle) and their histopathological changes in liver, kidney and bursa of fabricious of experimentally and naturally infected chickens were assayed.