الفهرس 
Introduction
Bone graftsOnly 14 pages are availabe for public view
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Abstract
This study was done to evaluate histologically the effect of synthetic nano-crystalline hydroxyapatite and that of synthetic microcrystalline hydroxyapatite on the healing of the induced jaw osseus defects in guinea pigs. Materials and methods: Normal thirty male guinea pigs (2-4) months old with an average weight of 250 grams were used in this study and randomly divided into three equal groups based on their time of sacrifice at15, 30 and 45 days postsurgically. All animals were operated on under general anaesthesia. The animals were subjected to implantation of synthetic nano-crystalline hydroxyapatite and synthetic microcrystalline hydroxyapatite mixed with saline solution into two induced bony defects about 3mm in diameter and depth through the right and left sides respectively. After the animals were sacrificed specimens were immediately fixed in 10% formaline solution, processed and stained with Heamatoxylene & Eosin, and Mason Trichrome stain. Histological evaluation All the specimens were examined for evaluation of the healing of the jaw defects. The histolgical sections of the control group revealed that healing of the bony cavities proceeded in a normal sequence of bone healing starting from 2 weeks and completed at 6 weeks. There was gradual increase in the formation of bone trabeculae and decrease in the amount of granulation tissue. In the study groups, there was early and faster formation of bone than in the control group Comparing the results of the control group and that of the microcrystalline hydroxyapatite group with the nanocrystalline hydroxyapatite group it was proved that healing was faster in nanocrystalline hydroxyapatite one. Conclusion Healing of the induced jaw osseous defects in guinea pigs was faster in nanohydroxyapatite graft material compared with synthetic microcrystalline hydroxyapatite.