الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Objective: This study aimed to assess immunohistochemically the postnatal chronological expression of stem cells in mouse submandibular salivary glands based on prominin-1 (CD133+). Results: Stem cell marker prominin-1 was expressed during different developmental stages in mouse SMG tissue. At birth duct cells were positive to prominin-1. Also, prominin-1 showed conspicuous positive immune results at the intercalated duct and striated duct cells of male/female glands at 4 weeks after birth compared to that of excretory duct cells which showed negative results. The granular convoluted tubules showed positive immune results at 8 weeks after birth in male glands. Acinar cells expressed prominin-1 at 4 and 8 weeks after birth in male glands only while myoepithelial cells expressed prominin-1 in male/female glands at 4 weeks after birth and to female glands at 8 weeks after birth. Endothelial cells of blood vessels expressed prominin-1 at all stages of development. Conclusion: Prominin-1 stem cell marker is important in SMG development. Tracking this marker in a model of animal with SMG damage might figure out a new rule of this marker in regeneration and/or resistance of damage. Also, being able to isolate cells with stem cell capacity (using stem cell markers like prominin-1) will help us as researcher to apply cell-based therapies to treat xerostomic patients.