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Abstract Angiogenesis is a process involving the growth of new blood vessels from pre-existing vessels, plays important roles in many physiological processes such as wound healing, embryonic development and reproduction. The induction of angiogenesis is mediated by multiple molecules that are released by both tumor and host cells. Hematological malignancies affecting blood, bone marrow, and lymph nodes. there is an increase in the density of blood vessels from bone marrow in patients with hematological malignancies. Recent informations indicate that the increase of the blood vessels in cancers of the blood is an important part of the disease and it has prognostic value in many of these malignancies . Inhibition of tumor angiogenesis suppresses tumor growth and spread, and is used to help in the treatment of these tumors. |