الفهرس 
Substitution of other groups for the amino functionOnly 14 pages are availabe for public view
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Abstract
There is currently a great deal of interest in the chemistry of Mannich bases due to their wide range of biological and pharmacological activities. Several Mannich bases derived from cycloalkanones were prepared and studied from the pharmacological point of view. Chemotherapeutically valuable compounds in this class are a series of Mannich bases, such as spiractin, oxazidione, Be-2254, and moban. In addition, tert-Mannich bases of cycloalkanones are of considerable importance as intermediates in the synthesis of condensed heterocyclic systems, and of heterocycles of alkaloidal nature. However, the use of sec-Mannich bases as synthetic intermediates has been reported in a limited number of cases. The work presented in this thesis has focused on the exploring the synthetic potential of Mannich bases of cycloalkanones as intermediates in the synthesis of some new heterocycles of pharmaceutical interest. PART I: Utility of sec-Mannich Bases of Cycloalkanones in Synthesis of Mixed Mannich Bases and Fused Heterocycles with Ring Junction Nitrogen Atom. PART II: Synthesis and some Reactions of Bis- and Tris-(Mannich Bases) of Cycloalkanones.