الفهرس 
Systems inducing local inflammationOnly 14 pages are availabe for public view
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Abstract
Characterization of anti-inflammatory activities of Ginkgo biloba extract in mice Mus musculus. The persent study was undertaken to investigate the antiinflammatory activities of Ginkgo biloba GBE and its terepenoides components in BALBIc mice. The effects of material were analyzed by using several systems to induce local inflammation. Inflammtion was induced using three methods; Lipopolysaccharide (LPS) injection, Cytokine IL- 1 injection into dorsal air pouch, and asthma model. Effect of GBE extract on the cumulative percentage of mortality: Pretreatment with D-galactosamine on day 0 rendered the mice more sensitive to the effect of an LPS dose injected at 1 pglmouse on day 1. Subcutaneous adminsitration of 100mgKg of GBE performed 30min. before LPS injection; caused an increase in the 50% lethal dose of LPS from 2 pg in the mice treated with water to 4 pg with GBE treatment. Effect of GBE on leukocyte migration: An air-pouch was subcutaneously formed in the back of mice by injecting filtered air twice, when 10mglkg of GBE was administered intraperitoneally (i.). leukocytes migration was reduced by 46% in the pouch. The asthma model: Effect of GBE on in vivo antibody production: Mice were immunized at day 0 and day 14 through i.p. injection with OVA. On day 21, results showed no significant difference between the control and GBE administered mice in the serum levels of total and OVA-specific IgG and IgE indicating that GBE has no effect on antibody production. * Aller~en Challenge :- This study aimed at evaluation of the effect of GBE and terpenoids on BAL migration. After 21 days from the first immunization, immunized mice received intranasal (in.) dose of 200pg OVA. Twenty-four hours later, bronchoalveolar lavage (BAL), was obtained and analysed for leukocytes and eosinophils. 1. GBE treatments: A- GBE (10mgIkg) treatment produced no significant inhibition of leukocytes or eosinophils. GBE 100mgIkg treatment showed significant inhibition of both cells. B- When GBE was administered intranasaly at 1 Omglkg dose at the same time of the OVA application, profound inhibitions in both cells were observed.