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Abstract The male factor has been estimated to be the primary cause of a couple’s infertility in 30% of cases and contributory in an additional 20% . Semen analysis must be considered the most important single item in the evaluation of male infertility. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are parts of kreb’s cycle and are essential for biologic oxidations. They have been reported to be present in normal human semen with levels much superior to those seen in the blood. The aim of this work was to estimate seminal AST and ALT activites in fertile and infertile males, and to evaluate their diagnostic importance and correlations with some of the other semen parameters. To achieve this, 65 cases were selected and classified into four groups including three groups of infertile patients; oligozoospermic, asthenozoospermic and azoospermic groups, and a fertile group which served as control. The cases were subjected to detailed history, thorough clinical examination and routine semen analysis. AST and ALT levels in seminal plasma and in serum were determined colonmetrically accordingm to the method of Reitrnan and Frankel (1957). Also, testicular biopsy was done for the azoospermic patients to differentiate functional from obstructive azoospermic cases. |