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Abstract The basic functional unit of the liver is the liver lobule, which is a cylindrical structure several millimeters in length and 0.8 to 2 millimeters in diameter. The human liver contains 50.000 to 100,000 individual lobules.The liver lobule is constructed around a central vein that empties into the hepatic veins and then into the vena cava. The lobule itself is composed principally of many hepatic cellular plates that radiate centrifugally Imm the central vein. Each hepatic plate is usually two cells thick, and between the adjacent cells lie small bile canaliculi that empty into bile ducts in the fibrous septa separating the adjacent liver lobules .Also in the septa are small portal venules that receive their blood mainly from the venous outflow of gastrointestinal tract by way of the portal veins. from these venules blood Hows into flat, branching hepatic sinusoids that lie between the hepatic plates and then into the central vein. Thus, the hepatic cells are exposed continuously to portal venous blood .In addition to the portal venules, hepatic arterioles are present in the interlobular septa. These arterioles supply arterial blood to the septal tissues between the adjacent lobules and many of the small arterioles also empty directly into the hepatic sinusoids. |