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Abstract The present study deals with the suitability of some insecticides as grain protectants against the rice weevil Sitophilus oryzae L. and the rust red flour beetles, Triboliurn castaneum (herbst).Therefore, tests pertaining the toxicity, resistance and cross resistance, residual toxicity were conducted. In addition, the study included experiments on tile determination of some insecticide residues and tlie side effects of these insecticides or their residues on white rats. 3-Iaasecticidd Activip; cf Tested Compounds: Five OP compounds, three synthetic pyrethroids and two carbarnate iilscticides were assessed in tl~e laboratory as potential protectants against thc adults of 7’. castaneum and S. oryzae using two inetllods of application (i.e. treated surface method and exposure to treated wheat grain). According to LC50 values (obtained by treated surface method), pirimipllos inethyl was the most toxic compound to T. castaneum followed by chlorpyriGos, malathion cldorpyrifos-inethyl, cyflutlxi11 and cypermetlwk (LC5O(s: 0.007,0. 03 6,0.066, 0.088, 0.197 and 0.22 pg/cm2 respectively). The insecticides, methomyl, thiodicarb, permethin and cldorfenvinphos showed moderate to low toxicity (LC5ds: 1.1, 1.73, 5.66 and 8.8lPg/cm2 respectively). Against S. oryzae, cliloipyrifos-lnetllyl was the most toxic insecticide followed by pirimiphosmethyl, chlorpynf’os, malathion ’and chlorfa~vinphos. Using the teclhniquc of eqosure to treated wheat grain, insecticides can be arranged according to their tocxicities to T. casteneum as the following descending order: chlorpyrifosmethyl> chlorpyrifos> pirinliphos-methyl> cypemethrin> cyflutlzrin> malathion> thiodicarb or chlorfenvinplios> pernietllrin> methomyl. Slight differences in the potencies ofthe tested insecticides between adults and larvae were observed. Generally it can be concluded that, OP compounds were thc most effective insecticides against the tested insects and a head of them. |