الفهرس 
Signal transductionOnly 14 pages are availabe for public view
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Abstract
NHL is a disease of world wide distribution affecting all ages and both sexes and it constitutes the third most frequent neoplastic disease in Egypt.The protein encoded by the Bcl-2 (B-cell lymphoma/leukemia-2) gene is a major regulator of programmed cell death,the process by which many chemotherapeutic agents ultimately effect tumor cell kill.The Bcl-2 represents a new category of chemoresistance genes that regulate the normal physiologic pathway for programmed cell death and it was reported that there was a connection between Bcl-2 and the resistance to chemotherapy.So, Bcl-2 antisense therapy discovered recently and led to downregulation of Bcl-2 protein and improvement in symptoms of lymphoma. So, Bcl-2 antisense therapy may be the most important potential application to overcome chemoresistance.fie aims of the present work were to measure the cell lysate level of Bcl-2 protein in NHL patients, to analyze the rearrangement of the Bcl-2 gene by conventional cytogenetics, to study the association between Bcl-2 protein expression and chromosomal rearrangement and to evaluate the diagnostic utility of measuring Bcl-2 protein in NHL patients.