الفهرس 
Classification of ALLOnly 14 pages are availabe for public view
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Abstract
Central nervous system involvementhas came a major concern in the acute lymphoblastic leukemia in·childood.At initial presentation, only 5% of patients has evidence of CNS leukemia. CNS leukemia at diagnosis is a leading cause of failure to achieve remission and of subsequent relapse,and the long term survival of this group of patients is only half that of those without initial CNS disease. In children, the diagnosis of CNS leukemia is usually based on elevated white blood cell count in the CSF and determination of blast cell in the CSF, however, diagnosis of subclinical forms of CNS leukemia may be missed or delayed so we need a more sensitive indicator of CNS leukemia.Fibrpnectin,when determined in CSF at the .timeof diagnosis,appears to be of great significance for the prognosis of acute lymphoblastic leukemia.