الفهرس 
NeuroanatomyOnly 14 pages are availabe for public view
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Abstract
Changes in sexual and reproductive functions are frequently associated with diabetes in men and experimental animals. Erectile dysfunction has been estimated to occur in 35-75% of diabetic patients. Impaired spermatogenesis, loss of seminal emission and retrograde ejaculation have been described in about 50% in juvenile diabetic men. Autonomic neuropathy has been suggested to be responsible for bladder dysfunction, loss of seminal emission and retrograde ejaculation in diabetic patients and to be the primary causative factor in 75-85% of diabetic patients with erectile dysfunction. Although, the etiology of diabetic neuropathy has not been clearly established, there is a considerable body of evidence suggesting that endoneural hypoxia is involved. Increased production of reactive oxygen species and increased lipid peroxidation have been recently suggested to be responsible for nerve damage in diabetes mellitus. Sabeluzole is a novel benzothiazol derivative developed by Janssen Pharmaceutical Inc. It has antihypoxic and antiischaemic activities. In addition, preliminay results in our laboratory have suggested that sabeluzole has antioxidant effect. declare and stevens reported that sabeluzole improved- the axonal transport of the sciatic nerve in diabetic rats. Furthermore, EI-Gamal et a1 found that sabeluzole treatment improved bladder contractility and sex behavior in diabetic rats. Recently, we observed that early sabeluzole treatment did improve sexual and detrusor functions in diabetic rats. Previous studies have shown that insulin treatment failed to improve bladder or erectile function in diabetic men. In addition, a recent report on insulin treated and untreated diabetic rats revealed that nerve fiber degeneration occured only in rats given insulin. However, recent experimental studies reported that an immediate and/ or higher dose of insulin treatment improved the bladder and the sexual function in ST’-induced diabetic male rats. The present study is designed to evaluate the effect of sabeluzole and insulin therapy on sexual and reproductive functions in the male diabetic rats and to evaluate the ability of sabeluzole treatment to improve the erectile function in diabetic impotent patients.