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Abstract Cry structure det erainat ion of organj-c compw~nds has be,mi some f i f t y years ago, as Lr~~dyi f f r a c t i o n nlethods have provided a powerful tool f o r stuaying nct only the mamer in which the molecules of an orsanic cornpound are held together to form the crysi;alline solid? but $he manner i n which the at as are held t ug~tlier i n the systeematict co~?figurationw hich accou~tsf o r t h e physical groperties cf the crystal. Since then the contribution of crystallography t o the field of organic chemistry is beyond any doubt , Cliemis-try has now solid bzsis Cepe-ding on the arra~ge-merit of atoms as revealed. by crystal stmcture analysis, The chemistry o< rr,oJ.eculcs gave way t o the chemistry of interatomic rela-- %icr;o L,, i n which ineasured interatomic dhsta-aces and bodangles becane important parameters i n fuznishing the st ructural o r st ereochemical evidence for any coapound. Par[; icularly is this of irnport ence vrher~ a molecular compoinnd o f phzm,-,ce v-ti dv alue is being s-tudie d , The shape 2nd size of the molecule uf an orcanic compound is determined by ponetrical factors such as bond len$hs, |