الفهرس 
Hydroxylation reactionsOnly 14 pages are availabe for public view
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Abstract
1. The potentiality of 23 dBerent locally isolated fungi to transform progesterone to its I 1 a-hydroxyderivative (1 1 a-HP) was studied. Eight experimental fungi, namely Fusarium moniliforme, Mucor racemosus NRRL 3639, Aspergillus niger, A. terreus A. Ochraceus, A. fumigatus, Pelt icillium cory loplzilum and P. islandicam proved to be the active transformers compared to the other tested fungal isolates. Mucor racenzosus NRRL 3639 appeared to be the most active one where a yield of 1 la-HP of 45.4% was obtained. 2. The suitability of the fermentation medium for the bioconversion of progesterone to 1 1 a-HP was examined using five different media. The formulated medium composed of (gA) glucose 40, peptone l , yeast extract 1, MgS04.7H20 1, M2P04 0.75 , Asparagine 0.70 was found to be the most suitable medium for the bioconversion reaction. This medium was used as the basal medium. 3. Effect of inoculum size of the used experimental microorganism on the bioconversion of progesterone to 1 1 a-HP was investigated. A gradual increase in the yield of 1 la-HP was achieved by increasing the in oculum size from 1 to 2ml. Maxrnium yield was obtained by using 2 mll50ml medium. 4. The convertibility of progesterone to 1 la-HP with the most active microorganism during different transformation periods was tested. A radual increase in the yield of 1 1 a-HP was obtained between 24 and 48hrs. Maximum yield of 1 l a-HP was that obtained at 48hrs.