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Abstract
This work aims to study the effect of oral vitamin E (VE) administration (300 mg/kg b.wt.) to normal and acrylamide (ACR)-intoxicated rats (25 mg/kg b.wt.) for 21 consecutive days. The frequency of bone marrow micronucleus (MN) was determined as well as the levels of norepinephrine (NE). dopamine (DA) and serotonin (5-HT) were measured in different brain regions like (cerebral cortex, thalamus & hypothalamus, midbrain, pons & medulla oblongata and cerebellum). Treatment of rats with ACR significantly elevated the frequency of bone marrow MN. Moreover, VE administration decreased the MN frequency to be near the control values suggesting the ameliorative effect of VE against ACR toxicity. On the other hand, ACR-intoxication elevated monoamine levels in all discrete brain regions and at all experimental periods except NE level, which showed a significant reduction at 21 day of intoxication. Oral administration of VE after ACR-intoxication alleviated these disturbances near to the normal levels.