الفهرس 
review of literatureOnly 14 pages are availabe for public view
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Abstract
H. pylori is a gram negative spirally shaped bacterium. It is considered as the most common bacterial infection in human and known to be the most common important cause of gastritis peptic ulcer, non ulcer dyspepsia and gastric carcinoma.
The frequency and importance of gastric mucosal lesion in patients with chronic liver disease have been increasingly recognized in recent years.
IL-8 a potent leukocyte chemo–attractant cytokine produced by HP promotes PMN and MNL accumulation in gastric mucosa.
This work aimed to clarify the relation between HP and IL-8 production in various chronic liver disease lesions.
For this reason patients were classified into two groups:
GI: included 50 patients with CLD.
GII: included 30 patients dyspeptic patients without CLD.
GII were reclassified according to endoscopic finding into:
GIIa comprised non gastric dyspepsia group.
GIIb comprised gastric dyspepsia group.
All cases and control were submitted to the following.
Full history, clinical examination sigmoidoscopy and rectal mucosal snip, abdominal ultrasonography, gastroduodenoscopy with multiple mucosal biopsies and liver biopsy for patients with CLD.
Gastric mucosal biopsies were examined histopathologically for curved bacilli of HP cellular infiltration and associated pathology and culture of HP and assessment of IL-8 level in gastric mucosa.
There is no significant difference between male and female as regard to HP postivity but postivity is significantly high as regard to age.
No significant difference was observed in patient group as regard to degree of varices , Child grading ,gastric histopathology or liver histopathology .
Out of 50 patients with CLD 30 were found positive for H. pylori while 10 out 15 patients with non gastric dyspepsia, and 14 out of 15 patients with gastric dyspepsia were positive for HP.
Statistical difference in HP prevalence between patient with CLD and these with non gastric dyspepsia was insignificant.
IL-8 and cellular infiltration is highly significant as regard to HP density.