الفهرس 
REVIEW OF LITERATUREOnly 14 pages are availabe for public view
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Abstract
Chronic obstructive pulmonary disease (COPD) is a major world problem that has an increasing prevalence and mortality. An oxidant antioxidant imbalance has been proposed as a mechanism of lung injury in OPD. Considerable evidences now link COPD with oxidative stress, which
be defined as increased exposure to oxidant and decreased antioxidant pacities.
An increased oxidant burden in the lung is thought to arise from the accumulation of inflammatory cells in the lower respiratory tract, including d alveolar macrophages and neutrophils which show an exaggerated of oxygen radicals. These may contribute to parenchyma injury by injury and cell death, modifying and disturbing the structure and function of cellular and non-cellular components. A regulating factor in this oxidative stress is antioxidants, which thought to be depleted in patients with COPD.
The aim of the present work is to study serum level of oxidants (MDA,
nitric oxides) and antioxidants enzymes (GSHpx, GSHrd, CAT and SOD), vitamins (A, E, C) and selenium in patients with COPD to detect the relation of COPD to some risk factors, the presence of oxidant/antioxidant imbalance in patients with COPD and the relation of these oxidants-antioxidants to
(FEV1/FVC).
This study included 200 subjects. They were classified into two groups; Group I included 100 COPD patients (chronic bronchitis and emphysema). Group II included 100 healthy persons (normal controls).
The patients were classified into three degrees according to pulmonary functions;
Mild degree of COPD (38 patients).
oderate degree of COPD (50 patients).