الفهرس 
- GIT malignancies.Only 14 pages are availabe for public view
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Abstract
Cancer is responsible for about 17% of all deaths, and in any given year, nearly
one million Americans are under medical care for neoplastic disease Cancer pathology registry (1985 - 1989 N.C.I., showed that : bladder constituted 26.39% and is ranked as numer I,
followed by lymphoma and breast cancer as ranks 2 and 3 respectively. Breast cancer
came as ranks 3, however it came as number one in female malagnancies. The digestive
system is the third most common system constituting 14.27% of total malignancies in
N.C.I. pathology registry The search continues for an ideal tumor marker that can differentitate quantitively
the normal from the neoplastic condition, give organ specificity, shows a high degree of
sensitivity and be of prognostic value. This study evaluated serum levels of CEA and Ferritin by enzyme immunoassay
using the monclonal anitobdyt technology together with the serum level of AAT and AAG
using radial immuno differentiation, in patients with carcinomas of the breast, GIT and
urinary tract. The results were correlated with the clinical data and histopathological
findings. The aim of this work was to investigate the suefbllness of these tumor markers in
the assessment of the ~atientThe study included 97 individuals, 30 normal healthy controls, 67 patients
divided into 3 groups : Group A (n =21), breast cancer patients 20 patients were
females and one male only, Group B (n=21) GIT-malignant patients 16 patients
were males and 5 patients were females, Group C (n=25) urological malignant
patients, 18 patients were males and 7 patients were females, All patients had full
clinical examination, laboratory investigations, radiology and endoscopic
visualization biopsy and histopathologicl examination were done. The tumor markers elevated in breast cancer patients were : serum CEA, serum
AAG and serum AAT Elevated serum level of CEA showed the highest sensitivity (85.71%) in breast
cancer patients. Sensititivy of serum AAG, AAT and ferritin was 76.19%, 57.14% and
33.3% respectively