الفهرس 
* Flow cytometryOnly 14 pages are availabe for public view
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Abstract
Formalin fixed, paraffin embedded liver biopsy specimens from eighty one Egyptian patients were studied. They composed of 33 cir-”hotic livers, 8 dysplastic lesions and 40 hepatocellular carcinomas;HCC). Flow cytometric DNA measurements were performed to de-termine the diagnostic and potential biological significance in these le-sions. Of the eighty one cases studied, there were seventy one males and ten females. Their age ranged from 18 to 80 years with a mean of 49.2 years. The mean age of cirrhotic patients was less than that of pa-tients with dysplasia and that of HCC (40.6 years, 50.9 years and 54.7years respectively). Hepatitis B surface antigen (HBs Ag) positivity was equally distributed among the three gorups. DNA aneuploidy was observed in 6.1% of cirrhotic lesions, 25% of those with dysplasia and in 80% of HCCs. The DNA index (DI) in aneuploid cirrhotic and dysplastic lesions ranged from 1.20 to 1.25, while the DI in aneuploid HCC lesions ranged from 1.11 to 3.40. There was no correlation between DNA ploidy pattern and any of the demographic, serum results and pathologic features in this cohort. There was a statistically significant difference in the mean pro-liferative capacity (PC) between cirrhotic and dysplastic lesions on one side and the HCC group on the other side (P=0.0001). Also the mean PC of diploid HCC was significantly higher than that of diploid cirrhotic and dysplastic ones (P==0.0025). While the mean PC of cir- rhotic patients showing DNA aneuploidy was equal to that of aneu.