الفهرس 
Estrogens and Their Mode of ActionOnly 14 pages are availabe for public view
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Abstract
The woman’s life has accorded so much of care all through her life starting from childhood to the menopause which was considered the end of her path. Exhaustion of the ovaries and the decline in the level of estradiol is not a problem of fertility which may be desired by few, but the estrogens have central roles in the normal function of the cardiovascular, skeletal, central nervous and immune systems. So, it has been a goal of developmental pharmacology to discover an adequate estrogen replacement.
The conventional hormonal replacement therapy has shown many side effects as increasing the risk of both eridometrial and breast cancer The researches led to the new group of drugs known as “Selective Estrogen Receptor Modulators” which may replace estrogen without fear of any side effects.
The objective of the present essay was systemically review the biochemical nature of selective estrogen receptor modulators (SERMs), which include the estrogens, and the known mechanisms by which they can exhibit tissue-selective agonist/antagonist activities. The key concept is that each SERM exhibits a unique pharmacologic profile. Thereafter, the specific attributes derived from clinical data on the currently known SERMs are summarized. Recent data from the clinical realm are now allowing us to examine the properties of each SERM in detail. Clinical data, particularly related to the cardiovascular and reproductive systems, are supporting the unique profile of individual SERMs and yielding our first glimpses into the full therapeutic potential of this class of drugs.