الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 132 |  |  |
| | | from | 132 | | |
Abstract
In recent years the profiles of patients requiring surgical revascularization have changed. Patients are now older, have more extensive coronary artery diseases, have lower ejection fraction and have higher prevalence of unstable symptoms. So the existing methods of myocardial protection have to be reevaluated in the face of increasing mortality and perioperative infarction in this growing group of patients.
Intermittent antegrade warm blood cardioplegia is a promising addition to the growing field of myocardial protection. It provides the cardiac surgeon a means to reduce myocardial ischemia and reperfusion injury as well as allow proper visualization by the virtue of interrupting cardioplegic flow while performing the distal anastomosis. Disadvantage, may include inadequate delivery in cases of severe coronary artery stenosis, increased risk of neurological complications and increased use of vasopressors during cardiopulmonary bypass to maintain systemic blood pressure which is claimed by some investigators to increase the risk of internal mammary artery spasm.
The basic principle of this study is to evaluate the efficacy and feasibility of the relatively new technique namely intermittent antegrade warm blood cardioplegia at systemic normothermia and compare it with the conventional method of intermittent antegrade cold crystalloid cardioplegia with systemic hypothermia (28°C) in patients undergoing coronary revascularization for coronary artery disease.
Thirty patients with coronary artery disease who were candidate for isolated coronary artery grafting, were assigned to one of two groups. The first group which was referred to as the warm group included 15 patients, and they received warm cardioplegia; the second group also included 15 patients and was referred to as the cold group, they received cold crystalloid cardioplegia.