الفهرس 
Histology of boneOnly 14 pages are availabe for public view
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Abstract
Fluoride is rapidly distributed by the systemic circulation to the intracellular and extracellular water of tissues; however, in humans and laboratory animals, approximately 99% of the total body burden of fluoride is retained in bones and teeth. In teeth and skeletal tissue, fluoride becomes incorporated into the crystal lattice.Intake of fluoride at excessive levels for long periods of time may lead to changes in bone structure known as skeletal fluorosis. The development of skeletal fluorosis and its severity is directly related to the level and duration of exposure. Most epidemiological researches had indicated that an intake of at least 10mg/day for 10 or more years in needed to produce clinical signs of the milder forms of the condition. In a recent case report severe joint pain and stiffness in a 64years old man was attributed to a fluoride intake of approximately 50mg/day for 6 years This work focuses on the histological and histochemical changes of growing bone following administration of sodium fluoride and the protective role of calcium.