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Abstract This study is designed to assess the role of’ chromoendoscopy using Lugol ‘s solution and histopathological examination of distal third of’ the esophagus in improving the detection of’ esophagitis in endoscopy negative reflux disease patients. This study was conducted on a total of 65 patients who were selected from the 200 patients entered the study. ‘lucy were 3 1 males (47.7%) and 34 fcmalcs (52.3%) their ages were ranging from 1 5 years to 54 years with a mean value of 335±11 .2 years. They were divided into the following groups: Group I: This group include 35 paticnts[ 17 male (48.6) and 1 8 Female (51.4)] presented with one or more of’ reflux symptoms (heartburn, acid regurgitation. water brash and eructation) with more than 3 i’efli.ix episodes / week with normal endoscop) and -‘-ye chromoendoscopy (noted mucosal lesions). Two groups o F biopsies arc taken from this group as Following: Biopsy group a: Biopsies taken from stained areas (suspected normal mu co s a). Biopsy group h: Biopsies taken from unstained areas (suspected inflamed mucosa). Group II: ‘l’his group included 30 patients lacking reflux symptoms with normal esophageal mucosa on endoscopy and with normal chromoendoscopy. Biopsies are taken at the level of’ the Z—1 inc and one cm proximally in the squamous epithelium as control group. |