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Abstract
TTV is a newly discovered (1997), undeveloped, single-stranded, circular-DNA virus that is suspected to be associated with liver disease. TTV may belong either to an existing family, Circoviridae, or to a recently established virus family, the Circoviridae . The virus has primarily been isolated from the serum of patients with post-transfusion hepatitis of unknown etiology, and was named TT virus after the initials of the patient it was first isolated from
Many authors reported that TTV infection is widespread in the world population. The natural route of transmission of TTV is still uncertain.
Initially, the primary mode of TTV transmission was proposed to be transfusion. Later on, several other modes of non-parenteral transmission were suggested and studied and up till now, this dual mode of transmission could potentially facilitate widespread dissemination of TTV over the world
Little is known about the clinical significance and the natural history of TTV infection. The responsibility of the virus for specific liver disease is still debated
At present stringent donor selection and blood unit screening procedures have reduced the risk of transmission by blood and plasma products of transfusion-related viruses such as HBV, HCV, and the human immunodeficiency viruses 1 and 2 (HIVI1-2)
In our study, we tested the prevalence of TTV in ninety five blood donors, the samples were obtained from volunteer blood donors attending Kom El-Decka regional blood bank in Alexandria throughout the period of September and October 2004
The blood donors, from whom the samples were taken, were questioned for their age, sex,residence and occupation