الفهرس 
Pathogenesis of the burn wound:Only 14 pages are availabe for public view
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Abstract
Nitric oxide [NO] is a molecule well known for its involvement in the inflammatory response. It can be synthesized from L- arginine by either a constitutive isoform expressed physiologically or by an inducible isoform expressed only under inflammatory circumstances. Exposure to inflammatory mediators stimulates various cells to produce both iNOS protein and NO above steady-state levels.
This study examined the NO plasma levels in thermally injured female patients during a period of 15 days immediately post injury and the effectiveness of early surgical excision and grafting on its levels.
Examination of human plasma samples showed an evidence of an increase of the NO immediately after injury in thermally injured patients. This increase plays a major role in the pathological changes of burn trauma.
In this thesis, we found that the NO plasma levels reflect the severity of inflammation in the early stage of burn. We also found
that there is a closed relation between NO plasma levels and infection.
Assessment of the plasma levels of NO in both groups revealed that they decrease in the surgical group than in the conservative group. This results confirmed that the effectiveness of the debridement of injured burn skin and the healing process on the NO plasma levels.
Our examination in this study observed that the surgical procedure of burned patients are not stressful enough to cause a rise in NO plasma levels. We also documented that there is no correlation between NO plasma levels and BSA.
In conclusion, this study confirmed that NO production is increased immediately after injury. Minimizing the free radical NO plasma levels in burned patients depend on integrated effort of control of infection, early surgical excision of injured skin and skin grafting and healing process. The plasma levels of NO may be used as an indication of the severity of inflammation in burn injury. Serial determination of NO plasma levels could be relevant in early detection of sepsis after thermal injury.