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Abstract
A total number of 96 dogs examined for detection of hepatobiliary diseases. These animals were subjected to thorough clinical investigation, serum biochemical panel, postmortem, cytological, histopathological evaluation and ultrasographic examination. The present study classified these animals into clinical cases of hepatopathies and exprimentally drug-induced hepatopathies (carbon tetrachloride hepatotoxicity and paracetamol-induced fulminant hepatitis). Clinical investigations revealed panorama of clinical signs (weight loss, vomiting, diarrhea, icterus, lethargy, nervous signs, ascites, hemorrhagic diathesis). Ultrasographic examination displayed focal and diffuse hyperechogenicity in different cases and some clinical cases of hypoechogenicitv Serum biochemical panel showed marked elevation of transaminases, alkaline phosphatase, GGT, bilirubin (total and direct). There was a decrease in albumin and total protein in some cases.’ Postmortem, cytological histopathological evaluation demonstrated exaggerated inflammatory and degenerative changes. The present study verified the role of ultrasonography in diagnosis of hepatobiliarv diseases.