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Abstract Lung cancer is leading cause of cancer death in developed countries . the poor prognosis associated with this disease is closely related to the fact that most lung cancer patients are not identified until their malignancy has reached an advanced stage. Around 80% of patient with lung cancer have stage lll or IV disease at presentation , which excludes them from potentially curative surgical resection . Detection of the tumor at the an earlier stage leads to an improve prognosis patient presenting with stage Ia non – small cell lung cancer and undergoing surgical resection have a 5 year survival of around 60%.(2) . Recent advances have added to the understanding of the morphological and molecular characteristics of pre- invasive bronchial lesions and early lung cancer . Such information is being used to provide new tests for the detection of lung cancer at early or pre – invasive stages , and for identifying targets for therapeutic intervention that can prevent progression to advanced disease. |