الفهرس 
Type2 Diabetes MellitusOnly 14 pages are availabe for public view
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Abstract
Insulin resistance has been assumed increasing importance as a
risk factor for cardiovascular disease coincident with the dramatic
increase in the prevalence of obesity and diabetes.
Several observation studies have reported an association of insulin
resistance with low serum testosterone level in men (Ender et al.,
1996, Oh et al., 2002, Elaine et al., 2004). A link between
testosterone deficiency and diabetes has also been suggested with
the demonstration that men with type 2 diabetes have lower
testosterone level than weight-matched non diabetic control
subjects (Andersson, 1994).
In addition low testosterone may predict development of type 2
diabetes in men (Laaksonen et al., 2003). In men, hypogonadism
is associated with features of the metabolic syndrome but the role
of sex hormones in the pathogenesis of the metabolic syndrome
and diabetes is not well understood in contrast to the abundant is
literature on this relationship in women.
Given that low testosterone level is associated with metabolic
syndrome and type 2 diabetes mellitus and that aging is
accompanied by insulin resistance and decline in testosterone
secretion (Morley et al., 1997), we hypothesized that testosterone
is an important modulator of insulin sensitivity.