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Abstract
Premature infants frequently suffer from feeding intolerance and are exposed to nasoduodenal feeding and parenteral nutrition with their complications for prolonged times. Establishing enteral feeding is therefore a critical milestone during management of premature infants. Erythromycin, is a motilin agonist with prokinetic effect which improve feeding tolerance however its use should be reserved for only high risk preterm neonates with persistent and severe feeding intolerance while limiting the duration of exposure and ensuring long term follow up.