الفهرس 
Anatomy and physiology of the skinOnly 14 pages are availabe for public view
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Abstract
Today, wound management to avoid excessive scar formation is increasingly important. As Keloids and hypertrophic scars are severely annoying wound healing problems, either for doctors or patients, owing to difficulty in their management. This is attributed to the lack of consistent disease definitions, outcome measures, inadequate follow up and inconsistent therapeutic intervention.
Hypertrophic scar and keloids are pathological types of scars. Although both hypertrophic scar and keloids appear to be similar, however, they differ in many aspects; Keloid tends to extend beyond the wound boundaries and appears within the first year after injury, it tends to recur after excision and grows over years. While hypertrophic scar respects the original wound boundaries, appears earlier within few weeks after trauma, tends to regress over time and does not recur after excision.
A lot of theories were set to define the pathological nature of these scars, few of these are factors related to Tension induced fibroblast proliferation and excess collagen production. Also, hormonal factors, and factors related to over production of TGF-B which stimulates angiogenesis and fibroblast proliferation, as well as excess collagen production.
Many years later have seen increased understanding in molecular and biological mechanisms of keloid and hyperophic scar, This allowed for development of more specific therapeutic options with variable degree of success.. Many therapeutic modalities were tried either single