الفهرس 
titleOnly 14 pages are availabe for public view
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Abstract
IL-16 originally named lymphocyte chemoattractant factor is a CD8+ T cell derived cytokine (also produced by monocytes, oesinophils, respiratory epithelium, fibroblasts and other cells). that induces chemotoxis of CD4+ T cells, monocytes and eosinophils. Besides its chemotactic activity, this cytokine also induces T cell activation (shown as induction of expression of IL-2R, HLA class II molecules on CD4+ T cells) and aneryg (shown as suppression of MLR and decline in antigen induced proliferation of CD4+ T cells) T cell abnormalities induced by IL-16 are also observed in lymphocytes in patients with SLE.
IL-16 was found to be significantly elevated in synovial fluid from patients with rheumatoid arthritis. The unique property of IL-16 to bind to CD4 molecule exerting both stimulating and inhibitory effects on T cell activation may explain the discrepancy between large number of infiltrating T cells in synovial membrane and lack of T cell derived cytokines in RA- SF and may add to our understanding of pathophysiological findings.