الفهرس 
Materials and MethodsOnly 14 pages are availabe for public view
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Abstract
The oriental catfish, Ploiosus lineatus, is one of the most dangerous venomous fishes known in Red Sea and Suez Gulf. This work is the first trial recording the most important enzymes in the crude skin secretion of the oriental catfish i.e. cholinestrase, hyaluronidase, phospholipase AI and other as well as some biological properties i.e. hemolytic , edema-forming activities and ichthyotoxcitiy. Also, this study aimed at investigating the antitumour activity of the crude skin secretion against solid Ehrlich carcinoma. Gel fractionation of the crude skin toxin on sephadex 075.120 gave three main fractions. The LDioo and LDso values were found to be 41.8 ug and 27.9 ug/g b.w., respectively, in mice, while no lethality among animals was detected regarding the three isolated fractions (up to 1600 ug/g b.w). Treatment of tumoured animals with the crude skin secretion resulted in an increase in the life span of mice (1LS % 238.8 %), tumor growth rate (T/C % 27), the tumour growth delay time (T-C) value was 20 days and reduction in the tumour weight was 1.35 g only compared to untreated tumoured controls (5 g). A total number of 200 adult female Swiss albino mice were divided into four main groups: Gr. I NC (normal controls, 60 mice), Gr. II N-tr. (Normal-treated, 60 mice), Gr. Ill T (Tumored, 20 mice) and Gr IV T-tr. (Tumored-treated, 60 mice).