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Abstract Threatened abortion is one of the major problems in obstetrics and applies to (1/3) of all pregnancies. Half of these pregnancies will continue pregnancy beyond viability while the other half will tenninate in spontaneous abortion. Expulsion of non-viable gestations is frequently delayed for weeks, leading to problems of prolonged vaginal bleeding, infection and patient anxiety. Therefore, early identification of non-viable gestations is important for determining which patient deserves ’uterine evacuation.Slow fetal heart rate in the first trimester is associated with a poor pregnancy outcome and a high probability of fetal demise before the end of the first trimester.The aim of this stiidy is to determine whether the correlation of ultrasonography for assessment of the mean gestational sac diameter, crown-rump length and fetal heart rate, color Doppler together with a single measurement of serum progesterone, human chorionic ’gonadotrophin and CA-125 levels, are useful as prognostic values in the prediction of pregnancy outcome among cases of first and early second trimester threatened abortion.The study included 120 pregnant females between six and fourteen weeks. One hundred of them were diagnosed as threatened abortion in the first presentation for them with a living fetus and the other 20 pregnant females were of low risk normally ongoing pregnancies and shared in the study as controls. All case were subjected to history taking, thorough physical examination, ultrasonographic examination for the MSD, CRL |