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Abstract
Hepatocellular carcinoma (HCC) is one of the most common cancers in the world and it is the most common primary nalignant tumor affecting the liver. Its occurrence is always linked to cirrhosis, chronic infection with hepatitis B and C viruses.
Tumor markers are potential screening tools that are widely used early diagnosis of tumors. The aim of ideal tumor marker estimation in HCC is early detection (surveillance(, particularly in the higher risk groups.
While AFP is a commonly used tumor marker in the detection of HCC, about 35 – 40% of HCC patients may have normal AFP. In addition, AFP may be elevated in non-malignant liver disease, so, AFP is still not a reliable indicator for the detection of HCC particularly with small and early HCCs.
This study was conducted in the aim to evaluate the rate of another tumor marker of HCC, which is called insulin-like growth factor-2, in early detection of HCC.
The study was carried out on 87 subjects. These subjects were divided into 3 groups:
* Group I: included 35 patients with cirrhosis.
* Group II: included 35 patients with cirrfotic HCC.
* Group III: included 17 age and sex matched healthy controls.