الفهرس 
AnatomyOnly 14 pages are availabe for public view
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Abstract
Improvement in the treatment and outcome of patients with breast cancer requires the development of diagnostic tools that can help in the differentiation between benign and malignant breast lesions in a noninvasive and reliable manner.
MRS has the unique ability to measure the biochemical content of living tissue in a dynamic and non invasive manner. This technique has provided substantial information on cellular metabolism and energy status in a variety of tissues and organs and, in particular, in tumor tissues and malignant cell cultures. The ability to follow the cell metabolism pattern in malignant cells before, during, and after drug treatment may assist the prognosis of treatment success.
This opens a new avenue for identifying the metabolic profiles of breast tumors with more exact anatomical localization and spectral data on tumor metabolism. The applications of these techniques can also be extended to a non invasive metabolic investigation of other cancers.
Distinct alternations in metabolite content have been observed in breast cancers but not in benign lesions of the breast. These alternations include increased content of phosphomonoesters and phosphodiesters detected by 31P MRS and increased content of composite choline detected by 1H MRS.