الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
Much controversy existed about the relationship
of thyroid disease and asthma. Based on clinical observations
Abrhamson (1941)3 state~ that asthmatics got worse·
with hypothroidism and were better with hyperthyroidism,
while Feinberg (1944) 88 mentioned that the hyperthyroid
state owing to its general increased met.eboLdc activ{ty .. ·
and nervous irritability might be apotent factor· in
maintaining the asthmatic state and that the removal·
of the hyperthyroid state may cure asthma. Abbasy et
- .
al., (1967)2 found normal B.M.R. (basal metabolic rate).
in sedated asymptomatic asthmatic children.
Settipane et al. (1972)~66 reported five adult
patients with severe asthma considered intractable untill
the diagnosis and therapy of an associated hyperthyroidism
resulted in prompt and striking impr.ovement a few days
after hyperthryoidism had been treated and controlled
with propyl thiouracile. Ismail et .al. . (1974145, 1977146
and 1980147) reported increase in the peak flow rates
of adult asthmatics following the administration of small
doses of triiodothyronine Which t.hey s·uggested. as a useful
,
adjuvant to antiasthmatic drugs 1 thus· allowing a material
reduction in the amount of bronchodilatorstheir patient
were in need of.
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(244)
The present work was carried out aiming to investigate
the functional state of the thyroid gland in patients
with chronic obstructive lung disease utilizing highly
specific and recent methodologies. The technique is highly
specific and is not affected by prior administration
of iodine containing medications (e.g. expectorant) as
with P.B.I. (protein bound iodine) measurements.
Fourty six patients out of 80 patients (57.5%)
with chronic obstructive pulmonary disease included in
this study showed high levels of T4 and/or T3· The rest
were euthyroid (34 patients = 42.5%). No one patient
included in this study showed low level of T4 and/or
T
3
• Trials to explain these findings were attempted and
it was concluded that an euthyroid state is essential
for normal bronchial wall responsiveness to various
stimuli.
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(245)
RECOMMENDATIONS
1- Every case of intractable bronchial asthma should
be investigated for the level of thyroid hormones
and if found to be· high. antithyroid drugs should
be sought for.
2- Fromour own results and the previous works reported
we feel that the final work about thyroid-asthma
interrelationship is not mentioned and the whole
subject needs to be fully reviewed on a larger
number of patients in various situations e.g.
during asthmatic attacks. during the free periods inbetween. during status asthmaticus and in chronic
cases.