الفهرس 
Diabetes MellitusOnly 14 pages are availabe for public view
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Abstract
AIM OF THE WORK AND SCOPE OF THE THESIS
Human hemo~lobin is less heterogenous, 90% of
hemoglobin is HbA in adults, 2.5~ is HbAz, 0.57. is Hbf.
Three minor components of normal Hb HbA1_, Hb A1b and Hb A1~
were first identified by Allen et al. (1958) I as fast moving
components in chromatographic system utilizing the ion exchange
resin IRe-50. The major component of these minor components
is Hb A1c which represents 5-67. of the total Hb.
Holmquist and schroeder (1966), reported that Hb A1C
differed from the major hemoglobin [Hb A (~2 B2)] by having
an unidentified compound bound to terminal nitrogen of the
Beta chain through a Schiff base linkage. Bookchin et al.
(1968). showed that B-chains have added hexose. Bunn et a1.
(1970), identified the blocking groups as glucose and
rnannose. The blocking groups were found to reduce greatly
the reactivity of Hb A1c with 2-3 diphosphoglycerate resulting
in an hemoglobin with high affinity for oxygen.
A relation ship between the fast moving components of
hem~globin and diaQetes mellitus was first observed by Huisman
and Dozy (1962). They found 2-3 folds increase in the
concentration of Hb A1c in 4-tolbutamide-treated diabetics.
(2)
These findin~ were confirmed in insulin de~ndent
diabetic adults by Rahbar et al. (1968) and Trivelli et al.
(1971) and in diabetic childern by Paulsen (1971).
The present work was conducted first, to find out the
avarage level of Hb A1C in the blood of appararitlyhealthy
non diabetic Egyptians and to compare this with those of
diabetic insulin- and non insulin dependent patients. It has
also been desirable to investigate the relation between the
glycosylated haemoglobin and the blood glucose levels in the
fasting state in the diabetics and in non diabetic subjects
and whether certain factors e.g. age, age of onset of the
disease, its duration and type of treatment would have an
influence on the glycosylated hemoglobin levels.
Our study was conducted 1n (1984). on 75 carefully
selected diabetic cases presenting the different types of
diabetes besides 25 apparantly healthy subjects to serve as
a reference group. The clinical and the laboratory procedures
were carefully assessed in order’ to get reliable
results.
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