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Abstract AntithroJlbin In belong. to the c1a.•• o~ ,Berin. p;roteas,. inbibi tors in plalilla (ao •• ~OI 1.171). It ill an alpha·2-g1obl,llin 0\ w1tb molecular weightot approl[l_~.ly ’5.000 cklton., llnd...h.•a. lt Ufe Df 96 hour. ·In ’the clr~l.t~on. Afttlt:hrOilbin III concentration in normal pI •••• b 0.13-0.40 911/1 although th18 vari •• w;Ltn age a.nd IIV.I(. (lie GalLa aaao uipl.t;~, ~,.~). Ha••odial.ysi8 patient. ”’1” ahow II. paradoxical OCCl.n:ance of: haeaorrnaqic .nd t.hroJlbotic co~,lic.tion:- tboey or have gastrointestinal bleedinq but at the sa•• tiJle tJ\II:1r ”a.’cular .ocelll’ may bt!colle occluded. Detectiv. platelet function a:nd low At III could contriJ:lute. to the par.aloxical occurance Df these complicatlon~IKDud.enat 11.1., Lt••, ..0 woo .t a1” 1”2). Dealing .with the level. o’f plas_ At III; in h_edialysed patient.. h~v. ~.fl cQnuQvoraial (iJ’029”.” et &1•.; 1177., aE’aAdt .t &l•.; 1’11, Kau4••• at, .1., :L•• I ••• Daaa! .t .1., 1”.). Br.Ddt e~ al., (l,tll) reported that. dillyei. c,auaa. a. aignificant decrease in At III levels. In contra.t ~rey at. II. C19U), llD4 woe at II. 11”5) fownd that At III levals ~.crea88d prior to dIalysis and i_proved after cUalyets.t1’Orgaa •• at •.1. (ltI5) r$por’tlild that the increase in At III i8 cor.rolponding to increase |