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Abstract Summary In the present study serum retinol level was assessed in 40 children with type I diabetes compared with 20 normal age and sex matched controls. Serum retinol level was significantly lower in diabetics than in nondiabetic controls. Serum retinol level was significantly lower in poorly controlled than in well-controlled diabetics. Serum retinol level was significantly correlated with both the duration of diabetes mellitus and HBA1c. There was a significant correlation between HBA I c and duration of diabetes. There was not significant difference of serum retinol level between male and female diabetics. There was not significant difference of serum retinol level between diabetics with vitamin A supplements and those without vitamin supplements. (124) There was significant correlation between serum retinol and creatinine in poorly controlled diabetics while there was not significant correlation between serum retinol and creatinine in well controlled diabetics. There was significant correlation between retinol and BMI in diabetic children while there was not significant correlation between retinol and BMI in normal controls. All patients and controls had normal liver, kidney and thyroid functions except only one diabetic patient with renal impairment. Conclusion Poor glycemic control is probably the major cause of lowered serum retinol level in children with type I diabetes. This study shows that poor glycaemic control clearly influences the growth and body mass index of diabetic children. This study shows an intimate relationship between vitamin A status, degree of glycaemic control and growth pattern of diabetic children. (125) Recommendation Strict control of type I diabetes is an essential process for improving serum retinol and growth in diabetic children. So it is recommended to: •Monitor the degree of diabetic control by measuring glycosylated Hb ”HbA lc” every 3 months with the aim of keeping it within the normal range. •Periodic measurement of serum retinol together with HbAie •Periodic assessment of weight for age, height for age, weight for height and BMI of diabetic children. •Nutritional education for parents and family of the diabetic child and whenever feasible for the child himself. |