![]() | Only 14 pages are availabe for public view |
Abstract Pregnancy induced hypertension is a disease of late pregnancy with increased maternal and fetal morbidity and mortality. An abnurmali ty of the placenta with abnormal cytotrophoblast differentiation has been lmpl icated as the underlying cause of pregnancy induced hypert(’n si on, The failure of rrophoblast ill vagi on and absence of the phyainl ogie al adaptation of the spiral arteries has been regarded as responsible for placental pathological changes and the reduced utero placental blood flow in pregnancy induced hypertension. Studying of the umbilical artery blood flow ve locimetry ami vascular resistance as determined by Doppler hove been related. to placental micro- VIISCU latur e. An abnormal umbilical artery waveforms reflected increased vascular resistance caused by inadequate physiological changes in the sp iral arteries which was asso ciated with an obliteration of the srnul l arteries of the tertiary villi of the pl~centa. Maternal hypertension is associated with high res istance ~n the umb iJical artery wi th sign j ficant increase in Doppler indices. The 111m of this work was to study the pattern of umbil ical artery Doppler ve locirnctry In cases cornpl icate d by pregnancy induced hypertension and norm oterisi vc cases .and compared with the pi acen tal pathology of these cuse s. The study included twenty women with pregnancy induced hypertension and twenty normotensive women as a control in rhe third trimester of pregnancy. They were subjected to complete history, general, obstetrical examination, laboratory investigations and ultrasound examination. Duppl er study of the umbilical artery blood now ve locimctry was done using continuous motle of Dop pler, After de livery the placenta was taken and subjected to pathological examination, In this study there was significant increase in the degree of hypertension and proteinuria between cases and control. There was signi Iic an t mer ease III Doppler indices (P<O.O 5) in the hypertens ive cast: 5 than the control. There was aiguificaut mcrease III Doppler indices (SiD, Pulsatility index and pourcelot index) with. increasing degree of hypertension and proteinuria. |