الفهرس | Only 14 pages are availabe for public view |
Abstract Our study included 25 patients with emphysema diagnosed using clinical, functional and radiological examination, and “5” healthy male volunteers as a control group. Patients subjected to both pulmonary function testing and HRCT with quantification of emphysema using density mask program to calculate LAA% in three zones of lungs (upper, middle and lower). Data collected subjected to statistical analysis revealing that: 1- Emphysema is associated with increased total lung capacity and residual volume both absolute and percent of predicted. 2- Emphysema is associated with decreased expiratory flow rates and diffusing capacity for carbon monoxide. 3- There is highly significant positive correlation between LAA% and both total lung capacity and residual volume. 4- There is highly significant negative correlation between LAA% and expiratory flow rates and diffusing capacity for carbon monoxide. 5- Linear regression find out the predictors of the level of total LAA% those were the diffusing capacity for carbon monoxide percent predicted and forced expiratory volume in the first second/forced vital capacity. 6- LAA% in upper and middle lung zones are more correlated with DLCO% and DLCO/VA than the lower lung zone. 7- Small airway function FEF25-75% are mostly correlated with LAA% in the middle and lower lung zones than in upper lung zone. (121) Recommendations 1- Study of distribution of lung density and mass in patients with emphysema using HRCT. 2- Study of HRCT scores of emphysema and oxygen desaturation during exercise testing. 3- Study of comparison of LAA% between inner and outer segments of the lung in patients with emphysema and contribution to pulmonary functions. 4- Study of quantification of emphysema with three- dimensional CT densitometry and comparison with two-dimensional analysis and pulmonary function tests. 5- HRCT for all patients of COPD for accurate diagnosis and quantification of emphysema. |