الفهرس 
EMPHYSEMA DEFINITIONOnly 14 pages are availabe for public view
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Abstract
Our study included 25 patients with emphysema diagnosed using
clinical, functional and radiological examination, and “5” healthy male
volunteers as a control group.
Patients subjected to both pulmonary function testing and HRCT
with quantification of emphysema using density mask program to calculate
LAA% in three zones of lungs (upper, middle and lower). Data collected
subjected to statistical analysis revealing that:
1- Emphysema is associated with increased total lung capacity and
residual volume both absolute and percent of predicted.
2- Emphysema is associated with decreased expiratory flow rates and
diffusing capacity for carbon monoxide.
3- There is highly significant positive correlation between LAA% and
both total lung capacity and residual volume.
4- There is highly significant negative correlation between LAA% and
expiratory flow rates and diffusing capacity for carbon monoxide.
5- Linear regression find out the predictors of the level of total LAA%
those were the diffusing capacity for carbon monoxide percent
predicted and forced expiratory volume in the first second/forced
vital capacity.
6- LAA% in upper and middle lung zones are more correlated with
DLCO% and DLCO/VA than the lower lung zone.
7- Small airway function FEF25-75% are mostly correlated with LAA% in
the middle and lower lung zones than in upper lung zone.
(121)
Recommendations
1- Study of distribution of lung density and mass in patients with
emphysema using HRCT.
2- Study of HRCT scores of emphysema and oxygen desaturation
during exercise testing.
3- Study of comparison of LAA% between inner and outer segments of
the lung in patients with emphysema and contribution to pulmonary
functions.
4- Study of quantification of emphysema with three- dimensional CT
densitometry and comparison with two-dimensional analysis and
pulmonary function tests.
5- HRCT for all patients of COPD for accurate diagnosis and
quantification of emphysema.