الفهرس 
Cytomega lovirusOnly 14 pages are availabe for public view
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Abstract
Introdu~tiolt 1
INTRODUCTION
HCMV is a DNA virus wbich beloegs to the Herpes virus family. It
replicates in the nucleus of tbe cell, It is specific for bumen tissue. M in
other herpes viruses, despite tbe development of a good immune
response, viral shedding after a primary infection normally persists for
montbs, even years, until the infection eventually becomes latent (Wolf
and Sonneborn 1990).
Primary HCMV infections are generally (95%) asymptomatic and thus
go undetected (Stagna et al., 1982) (StlgDO et al., 19”85). HCMV
infections, caused by infusion of infected blood, are rarely symptomatic
in immuDologically coaipetent transfusion recipients (Bayer et al., 1’984)
(Wolf and sonneborn 1990);
Yet HCMV infections can cause significant morbidity and mortality
in lmmunocompromised patleets. The clinical maalfestations in those
patients are in the form of, pneumonitis, retinitis, encephalitis and
disease of the gastrointestinal tract. HCMV prenatalrnfectioDs may cause
Jaundice, hepatosplenomegaly, thrombocytopenia and microcephaly.
Prenatally infected infants which are asymptomatic at birth may develope
hearina defects aDd mental retardatlon (stagno ,et at, t9’8S).
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