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Abstract This study included 28 healthy, non-diabetic and not obese subjects (controls), group, I. Also, they included 70 obese persons who were classified after applying the National Diabetes Data group (1979) on the results of their oral glucose tolerance test (OGTT) into three subgroups Group, II included 29 persons who were obese with normal glucose tolerance (NGT). Group, III: included 2q obese subjects with impaired glucose tolerance (IGT). Group, IV: included 17 obese persons who were diabetics. ¥or the controls and all obese subjects, in addition to OGTT, serum albumin and fructosamine levels were estimated. The results of this study showed 1. Serum albumin in obese SUbjects with NGT, group, II was not significantly different from the corresponding levels of controls. While obese with IGT or who were diabetics had significantly lower serum albumin than controls or ob ••• with NGT. 2. Serum fructosamine levels were not correlated with age or sex in all the investigated groups, but were positively correlated with fasting plasma glucose levels 1)1 in all the studied groups. The fructosamine serum levels in obese subjects with NGT or IGT were not significantly different from the corresponding levels in controls. This results points to a failure of this fructosamine test to detect cases of impaired glucose tolerance. However, the 17 obese diabetics investigated in this study, who were all uncontrolled, showed serum fructosamine levels above the range of control subjects (18 -37 mg.!dl.). This finding pOints’to the ability of usage of this test as a diagnostic aid for differentiation between glucose intolerance and frank diabetes mellitus in obese subjects. |