الفهرس 
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Abstract
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Summary & Conculsions
SUMMARY AND CONCULSIONS
This study was conducted on 100 newborns mothers pairs classified into
one control group ”Full term healthy newborn” and four test groups :
Preterm, SGA. preeclampitic and diabetic group. 1.25 dihydroxy vitamin D3.
calcium and intorganic phosphorus levels were estimated in both cord and
maternal blood samples.
In premature groupboth cord and maternal ”1.25(OH)2D3 and calcium”
were significantly lower than corresponding values of control group. There
was positive correlation between cord maternal ”1.25(OH)2D3 and calcium”.
Also a significant lower levels of both maternal and cord ”1.25(OH)2D3
and calcium” were found in SOA newborns and was consistent with positive
correlation between cord vitamin D and birth weight. This is consistent with
earlier findings of other authors which stated that reduced utero placental
blood flow in SGA infants may result in reduced fetal placental production of
1.25(OH)2D3.
Preeclamptic mothers and their newborns have also significntly lower
maternal and cord ”1,25(OH)2D3 and calcium” than the control group. There
was a positive correlation between cord 1.25(OH)2D3 with both cord calcium
and maternal 1.25(OH)2D3. The lower 1.25(OH)2D3 levels reflect placental
dysfunction caused by reduced vtero placental blood flow. Alternatively.
abnormal proximal tubular function resulting in diminished renal 1a
hydroxylation may be responsible for reduced level of 1.25(OH)2D3.
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Summary & Conculsiona
In diabetic group, both cord and maternal ”1,25(OH)2D3 and calcium”
were significantly lower than full term group values. This may be attributed to
insulin deficiency, which play a role in impaired vitamin D production,
because insulin itself may stimulate renal lu hydroxylase.
Significant correlation were found between cord serum 1,25(OH)2D3,
birth weight, maternal vitamin D and cord calcium in all the studied groups.
So in conclusion the vitamin D status of the newborn is influenced by
factors such as gestational age, growth status and maternal vitamin D as well as
overall nutritinal status. The studies also suggest the low vitamin D status of
the mother to be one of the fetaure associated with prematurity as well as
intrautrine growth ratardation. These findings stress the importance of safe
vitamin D supplies to pregnant women.
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