الفهرس 
MicroalbuminuriaOnly 14 pages are availabe for public view
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Abstract
Our study included thirty three cases of both sexes with age ranging from 25-45 years. They were classified
into two groups according to the presence of liver cirrhosis.
Group I: Included ten normal control cases; 6 cases were males and 4 were females.
Group II: Included twinty-three cases who had developed liver cirrhosis; 14 cases were males and 9 cases were females.
Group II was further divided into two subgroups according to the type of cirrhosis.
Subgroup II A: Included 17 patients with mixed liver cirrhosis.
Subgroup II B: Included 6 patients with liver cirrhosis due to chronic active hepatitis. Our cases were chosen free from renal impairment as guided by complete medical history, thorough clinical examination, routine urine analysis, blood urea and serum creatinine. Diabetes mellitus and other causes of microalbuminuria were excluded by complete medical history, thorough clinical examination, fasting and post-pradial blood sugar. The results showed that there were highly significant decrease in serum albumin in Group II and in both subgroups: Subgroup II A and Subgroup II B. Then all cases were investigated for liver function tests to confirm the presence of liver impairment in Liver needle aspiration biopsy was performed to all patients of Group II to confirm the presence of liver cirrhosis using Manghini technique. The study showed that liver cirrhosis is accompanied by impairment of liver function tests as pronounced by highly significant increase in serum bilirubin in Group II where P value 0.005, serum glutamic oxalacetic transaminase also highly significantly increased in Group II where P value < 0.005, in addition there was highly significant increase in serum glutamic pyruvic transaminase in Group II as P value ( 0.005 and serum alkaline phosphatase was significantly increased in Group II at P value ( 0.005). Also, the subgroup II A patients with mixed liver cirrhosis showed highly significant increase in serum bilirubin, serum glutamic oxalacetic transminase, serum glutamic pyruvic transaminase and serum alkaline phosphatase. Chronic active hepatitis also showed significant increase in serum bilirubin, highly significant .increase in serum glutamic oxalacetic transaminase, serum glutamic pyruvic transaminase and in serum alkaline phosphatase. But, there were no significant increase in liver function tests between the two subgroups: subgroup II A and subgroup II B.
The results showed highly significant increase in microalbuminuria in Group II patients with liver cirrhosis (mean value 35.54 + 15.27 ug/min) as compared to Group I control cases (mean value 4.65 + 2.27 ug/min).
Our study showed also that there were highly significant increase in albumin excretion rate in both subgroup II A and subgroup II B. Also, the results showed highly significant increase in albumin excretion rate in subgroup II A as compared to subarouo II 11_ So. we level of albumin excretion rate than that with liver cirrhosis due to chronic active hepatitis. from our study we can conclude that the presence of microalbuminuria is an early indicator of the developement of renal complication and early detection and treatment of renal failure. from our study we can suggest that patients with mixed liver cirrhosis are more liable for affection of the kidney than patients with liver cirrhosis due to chronic active hepatitis.