الفهرس 
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Abstract
SUlTllTlery and Conclusions
Alopecia areata (AA) is common form of Non-Scarring Alopecia
that appears equally in males and females of any age, although children
and adolescence are more commonly affected.
The disorder usually characterized by limited alopecic patches on
the scalp, but more severe forms may affect the entire scalp (Alopecia
totalis) or the whole body (alopecia universalis).
Treatment is challenging and aims at regrowth of hair in the
affected individuals.
There are various therapies for the disease but the effect of each
therapy differs from one patient to another, making a universal treatment
difficult to implement.
The treatment of AA with PUVA has been tried with variable
success, similar to PUVA therapy, NB-UVB has previously demonstrated
to be effective for number of other PUVA-responsive diseases including
Psoriasis, Parapsorasis, vitiligo .... etc, some studies reported that it is
better than PUVA in these diseases.
In this study we aim to det4nnine the efficiency of Narrow Band UVB
(NB-UVB) light therapy for’ptensive alopecia areata in comparison with
PUVA therapy. 1
”,
Thirty Patients_ with exten+e AA more than 40% were included and
categorized into two groups:-
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Group A :- included 15 patients, 7 patients with AA > 40 % scalp
involvement, 4 patients with AT and 4 patients AU. This group received
1
PUVA therapy 3 times a weak for three months.
Group B:- included 15 patients, 7 patients with AA > 40% scalp
involvement, 4 patients with AT and 4 patients with AU. This group
received NB-UVB therapy 3 times a weak for three months.
When we compared between the two lines after three months of
therapy we reported that number of poor results with NB-UV A was more
. ” (ten patients) than those with PUVA (three patients) and the relation was
highly significant.
Excellent results with PUVA were reported in eight patients while
reported only in two patients with NB-UVB so the relation was also ”,.
significant.
The comparison between the two lines according to mean of the
total cumulative dose and the number of sessions was highly significant.
The most common side effects reported in both groups were mild
burning erythema and mild iching.
In conclusion, PUVA can be used as an alternative therapy for
patients with extensive resistant alopecia. NB-UVB therapy is indicated
when there is contraindication for PUVA treatment (children, pregnant
women, hypersensitivity to psoralen),
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Recommendation
• Further studies on the effect ofNB-UVB as a treatment of AA with
long duration and more number of patients may show better results.
• Further study on the effect of the NB-UVB as a treatment ofAA
when combined with local or systemic psoralen.
• Further study on the effect of the PUVA as a treatment of AA with
longer duration and higher dose and tapering it gradually.