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Abstract
Blood platelets have several important functions. They adhere to sites of vascular injury, generate biological mediators, secrete their granule contents, form multicellular aggregates and serve as a nidus for plasma coagulation reactions. In order to carry out these tasks, the platelet undergoes dramatic structural rearrangements, utilizes multiple membrane receptors, which bind small molecule mediators, adhesive glycoproteins and constituents of the vascular subendothelium, and activates a network of complex signaling pathways. All of these events occur within seconds of vascular injury.
The inherited platelet disorders are a heterogeneous collection of rare diseases that are infrequently encountered in clinical practice. They are, however, fascinating abnormalities, which have taught us a great deal about normal platelet biochemistry and physiology .They include disorders of the platelet membrane, platelet granule packaging disorders, the hereditary macrothrombocytopenias, platelet signaling disorders and disorders of platelet coagulant function .
A qualitative abnormality of platelet function should be considered in patients with mucocutaneous bleeding in the absence of thrombocytopenia or von Willebrand disease. Antiplatelet drugs are the most common cause of acquired platelet disorders leading to bleeding. Uremia, hepatic cirrhosis, myeloma and related disorders , polycythemia vera , essential
thrombocythemia, and cardiopulmonary bypass have long been recognized as clinical situations in which platelet dysfunction.