الفهرس 
Material and methodsOnly 14 pages are availabe for public view
 |  | from | 123 |  |  |
| | | from | 123 | | |
Abstract
Summary
Summary
Leptin is 167 amino acids hormone, that is expressed and secreted exclusively from adipocytes, functioning as a metabolic regulator to control body weight through inducing satiety and influencing thermogenesis and energy expenditure (Zhang et al., 1994).
Both leptin hormone and insulin concentration increase with body fat mass diabetes mellitus is a syndrome of disturbed energy homeostasis caused by deficiency of insulin or its action and resulting in abnormal metabolism of carbohydrate, protein, and fat it is most common endocrine metabolic disorder of childhood and adolescence with important consequences on physical and emotional development (Sperling, 1996).
The aim of this study was to investigate the possible relationship between serum leptin levels in both obese diabetic type I diabetic mellitus and non-obese diabetic type I diabetic mellitus in children and young adolescents.
The study was carried out 71 subjects divided into 4 groups:
•Group (1): 13 patients with insulin dependant diabetic and obese.
•Group (2): 18 patient non-obese insulin dependant diabetic.
•Groups(3): 15 obese healthy (non-diabetic) subjects as a control group.
•Group (4): 25 non-obese healthy (non-diabetic) subjects as a control group also.
84
Summary
For each subject the following was done:
Full history and detailed clinical examination including age, sex weight, height, body mass index.
Routine laboratory investigation for diabetes including fasting blood glucose.
-Glucose tolerance test urine for sugar and ketones.
-Fasting serum leptin level.
-Type of therapy and doses of insulin and its regularity. The results were as follow:
Serum leptin concentrations are similar in diabetic and healthy control subjects.
Serum leptin level was positively correlated with:
(a)Obese diabetic group than non-obese diabetic.
(b)Obese control group than non-obese control.
(c)With in creasing BMI.
(d)Female sex.
(e)Age.
(f) With patient initial treatment with insulin and regular treatment. (g)Last stage of puberty in female.
On the other hand.
85
Summary
The leptin level was in decrease in:
1-Non-obese diabetic than obese diabetic.
2-Non-obese healthy control than obese healthy control.
3-With decreasing BMI.
4-In male sex than female.
5-With patient didn’t initial treated by insulin or irregular treatment.
6- Leptin concentration in males decreased in last stage of puberty but in females continuos in creasing in last stages of puberty.